Eosinophils in the dermis

Eosinophils in the dermis                 See DX Path for details of the conditions below

Large numbers in the dermis suggest arthropod bite including scabies, pre bullous pemphigoid and Well's syndrome or eosinophilic cellulitis.

Some increase is also seen in drug reactions, urticaria and so called deep dermal hypersensitivity reactions. Flame figures are orange deposits of eosinophilic basic protein seen in the dermis particularly in Well's syndrome

Arthropod bites

Parasitic diseases

Drug eruptions

Wells syndrome

Granuloma faciale

Urticaria

Urticarial pemphigoid

Churg-Strauss syndrome

Angiolymphoid hyperplasia with eosinophilia (histiocytoid hemangioma)

Accompanying some examples of anaplastic large cell lymphoma