Clear spaces between cells

Clear Spaces between cells in the Dermis.             See DX Path for details of the conditions below

Clear spaces between cells

These are sometimes known as clefts. They are a useful diagnostic feature with BCCs versus Trichoepitheliomas but can also be seen in melanomas and beneath the basement membrane in Lichen Planus where they are known as Max Joseph spaces.
Clefts are commonly seen in pink gouty tophi and Cholesterol deposits.Prominent clefts around cell nests in Spitz nevi can be helpful in diagnosis.
Needle shaped clefts are a prominent feature of Subcutameous fat necrosis and sclerema neonatorum in the subcutaneous fat.

An infiltrate of mucin

Pretibial Myxedema

Edema fluid