Exocytosis refers to the migration of inflammatory cells into the epidermis whereas Epidermotropism refers to the migration of malignant cells into the epidermis.
Exocytosis occurs in inflammatory diseases such as Eczema and Psoriasis but also in Erythema multiforme and graft versus host disease. Sweet's syndrome is another condition showing exocytosis but here the cells are neutrophils. Plasma cells can be seen in secondary syphilis. Eosinophils are prominent in the epidermis in bullous pemphigoid, allergic contact dermatitis, insect bite reactions, scabies, where they may form eosinophilic spongiosis.
Epidermotropism- We particularly think of epidermotropism and T cell lymphoma with atypical lymphocytes being found in the epidermis sometimes in nests as in Pautrier microabscesses. Histiocytoses can also be seen in the epidermis and the various conditions showing Pagetoid spread may sometimes also be exhibiting epidermotropism when the cell of oprigin is not a normal inhabitant of the epidermis.
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